Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease: The 'Heart of Soweto' hospital registry study

JG Lyons; K Sliwa; MJ Carrington; F Raal; S Pretorius; F Thienemann; S Stewart

Journal article

Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease: The 'Heart of Soweto' hospital registry study

JG Lyons, K Sliwa, MJ Carrington, F Raal, S Pretorius, F Thienemann, S Stewart

BMJ Open | BMJ PUBLISHING GROUP | Published : 2014

DOI: 10.1136/bmjopen-2014-005069

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Abstract

Objectives: To investigate if urban Africans displayed lower levels of atheroprotective high-density lipoprotein cholesterol (HDLC) when presenting with communicable versus non-communicable forms of heart disease (HD) as both acute infection and chronic inflammation reduce HDLC levels. Design: Hospital registry of 5328 de novo cases of HD over a 3-year period. Setting: Cardiology Unit, Baragwanath Hospital in Soweto, South Africa. Participants: A total of 1199 patients of African descent (59% women; 57.0±13.4 years) had fasting blood lipid levels (total cholesterol (TC), triglyceride, HDLC and low-density lipoprotein cholesterol (LDLC)) documented on admission. Serum inflammatory marker C re..

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University of Melbourne Researchers

Melinda Carrington Author

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Awarded by Medical Research Council

Funding Acknowledgements

The 'Heart of Soweto Study' registry was supported by the University of the Witwatersrand and unconditional research grants from Adcock-Ingram, the Medtronic Foundation USA, Servier, Bayer-Schering and BHP Billiton. All authors had financial support from independent funding bodies, including University of the Witwatersrand and unconditional research grants from Adcock-Ingram, the Medtronic Foundation USA, Servier, Bayer-Schering and BHP Billiton, for the submitted work. SS, MJC and JGL are supported by the National Health and Medical Research Council of Australia [Programme Grants 320860 and 631947 and Postgraduate scholarship 586739]. JGL is supported by the National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand. Baker IDI is supported by the Victorian Government's Operational Infrastructure Support Programme. KS and SL are supported by the MRC South Africa and the University of Cape Town.